Effect of Royal Jelly on Sperm Parameters in Aluminum-Treated Male Rats
DOI:
https://doi.org/10.22034/JATE.2020.36Abstract
Background: Aluminum (Al) metal is abundantly present in the earth’s crust. Aluminum is present in many manufactured foods and medicines and is also added to drinking water during purification purposes, and this has allowed its easy access into the body. Aluminum has been proposed as an environmental factor that may contribute to some diseases. Different forms of aluminum are environmental xenobiotics that induce free radical-mediated cytotoxicity and reproductive toxicity. Royal jelly is a substance produced by worker honey bees. If fed to an ordinary female bee in the larval stage, royal jelly will transform her into the queen bee. Scientific research on royal jelly has revealed that it benefits sexual performance.
Methods and Materials: Fifty adult male albino rats were used in this study. They were randomly divided into five groups. The first group served as control group (negative group). The second group was received 20 mg AlCl3 /kg body weight (positive group). The other groups were received the same dose of AlCl3 and subdivided into three groups according to the concentration of royal jelly (RJ). Three concentrations of RJ were investigated (50, 100 and 200 mg/kg). All treated doses were given orally by gastric intubation and the experiment was continued daily for 60 days. This study included the studying the sperm parameters in tail of epididymis, measuring the values of some hormones including testosterone, luteinizing hormone (LH) and follicle stimulating hormone (FSH) and estimate the level of malondialdehyde (MDA) in blood serum.
Results: The supplementation of aluminum-treated animals with the royal jelly resulted in an appreciable improvement in all the studied reproductive parameters, hormonal level and MDA. Moreover, increasing degree of amelioration was in correlation with the amount of progressive concentrations of royal jelly.
Conclusion: This study showed that RJ has alleviating effect and protective role in the condition of aluminium -induced oxidative stress.
References
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9. Nagaia T, Mizuho S, Inouec R, Inouec H, Suzuki N. Antioxidative activities of some commercially honeys, royal jelly, and propolis. Food Chemistry. 2001; 75: 237-240.
10. Khattab HAH, Abdallah IZA, Kamel GM.Grape seed extract alleviate reproductive toxicity caused by aluminium chloride in male rats. Journal of American Science.2010; 6(12):1200-1209.
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12. Ige FS, Achebe ER. The role of Allium cepa on aluminum-induced reproductive dysfunction in experimental male rat models. Journal of human reproductive scince. 2012; 5 (2).
13. Schiller NK, McNamara DB. Balloon catheter vascular injury of the alloxan- induced diabetic rabbit: The role of insulin-like growth factor-1. Molecular and Cellular Biochemistry. 1999; 202:159-167.
14. Silici S, Ekmekcioglu O, Eraslan G, Demirtas A. Antioxidative Effect of royal jelly in cisplatin-induced testes damage. J. Urology.2009; 74(3):545-551.
15. Seed J, Chapin RE, Clegg ED. Methods for assessing sperm motility, morphology and counts in the rat, rabbit and dog: a consensus report. Rep.Toxicol. 1996; 10: 237-244.
16. Blom E. A one-minute live–dead sperm stain by means of eosinnigrosin. J.Fertil. Steril.1950; 1:176–177.
17. Linder RE, Klinefetter GR, Strader LF. Dibromoacetic acid affects reproductive competence and sperm quality in the male rats. Fund. Appl.Toxicol. 1995; 28: 9-17.
18. Amirshahi T, Najafi G, Nejati V. Protective effect of royal jelly on fertility and biochemical parameters in bleomycin-induced male rats. Iran J Reprod Med. 2014; 12 (3):209-216.
19. Zhu YZ, Sun H, Yang Fu , Wang J, Song M, Li M, Li YF, Miao LG. Effects of sub-chronic aluminum chloride on spermatogenesis and testicular enzymatic activity in male rats. Life Sciences. 2014; 102: 36–40.
20. Gutteridge JMC. Lipid peroxidation and antioxidants as biomarkers of tissue damage. Clin. Chem.1995; 14:1819-1828.
21. Steel ROD, Torrie JII. Principles and produces of statistics. New York: Macgraw-till Book Company.1960; Inc. 76.
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27. Dawson EB, Ritter S, Harris WA, Evans DR, Powell LC. Comparison of sperm viability with seminal plasma metal levels. Biol. Trace Elem. Res.1998; 64: 215–223.
28. Zatta P, Lain E, Cagnolini C . Effects of aluminum on activity of Krebs cycle enzymes and glutamate dehydrogenase in rat brain homogenate. Eur. J. Biochem.2000; 267: 3049-3055.
29. Yousef MI, Kamel KI, El-Guendi MI, El-Demerdash FM. An in vitro study on reproductive toxicity of aluminium chloride on rabbit sperm: the protective role of some antioxidants. Toxicology. 2007; 239: 213-223.
30. Bidlingmaier F, Helmuth GD, Wolfgana E, Ursula K , Dietrch K. Testosterone and androstenedione concentrations in human testis and epididymis during the first two years of life. Journal of Clinical Endocrinology and Metabolism.1983; 57(2).
31. Hassan AA. Effect of royal jelly on sexual efficiency in adult male rats. Iraqi Journal of Veterinary Sciences.2009; 23 (2):155-160.
32. Elnagar S A. Royal jelly counteracts bucks’ “summer infertility” Animal Reproduction Science. 2010; 121: 174-180.
33. Moradi AR, Malekinejad H, Farrokhi-Ardabili F, Bernousi I. Royal Jelly improves the sperm parameters of ram semen during liquid storage and serves as an antioxidant source. Small ruminant research.2013; 113: 346-352.
34. Zahmatkesh E, Najafi G, Nejati V, Heidari R. Protective effect of royal jelly on the sperm parameters and testosterone level and lipid peroxidation in adult mice treated with oxymetholone. Avicenna Journal of Phytomedicine.2013; 4(1):43-52.
35. Aitken RJ, Baker MA, Sawyer D. Oxidative stress in the male germ line and its role in the etiology of male infertility and genetic disease, Reprod. Biomed.2003; 7: 65-70.
36. Abdul-Rasoul E M, Hassan N A, Al-Mallah K H. Effect of aluminium chloride on sexual efficiency in adult male rats. J. Edu. Sci.2009; 22 (4): 27-44.
37. Ebisch IMW, Pierik FH, Jong FH, Thomas CMG, Steeger-Theunissen RPM. Does folic acid and zinc sulphate intervention affect endocrine parameters and sperm characteristics in men? Intern J Andro.2006; 29(2):339-345.
38. Lenzi1 a, Picardo M, Gandini L, Dondero F. Lipids of the sperm plasma membrane: from polyunsaturated fatty acids considered as markers of sperm function to possible scavenger therapy. Human Reproduction Update.1996; 2: 246–256.
39. Aitken RJ, Koppers AJ. Apoptosis and DNA damage in human spermatozoa. Asian J. Androl.2011; 13: 36–42.
40. Shostia AM. Role of reactive oxygen species in regulation of spermatogenesis and fertilization in mammals. Ukr. Biokhim. Zh.2009; 81: 14–22.
41. Kim JG, Parthasarathy S. Oxidation and the spermatozoa. Semen. Reprod. Endocrinol.1998; 16: 235–239.
42. Graham J. (Ed.). The Hive and the Honey Bee. Dadant and Sons, Inc., Hamilton, IL.U.S.A.1992; 1324 pp.
43. Inoue S, Koya-Miyata S, Ushio S, Iwaki K, Ikeda M, and Kurimoto M. Royal Jelly prolongs the life span of C3H/HeJ mice: correlation with reduced DNA damage. Exp.Gerontol.2003; 38(9):965-969.
44. Cavusoglu K, Yapar K , Yalcin E. Royal jelly (honey bee) is a potential antioxidant against cadmium-induced genotoxicity and oxidative stress in albino mice.2009; J Med Food.,12(6).
45. Liu JY, stemmer KL. Interaction between aluminum and aic or copper and its effects on the pituitary-testicular axis. II. Testicular enzyme and serum gonadotropin assay. Biomed. Environ.Sci.1990; 3 (11).
46. Barrett K E, Boitano S, Barman S M , Brooks H L. Ganong's Review of Medical Physiology. 23th Edn. . New York: McGraw .Hill.2010.
47. Shahraki MR, Palan Mony EY, Zahedi Asil S, Sarkaki AR, Sarkaki AR. Effect of aluminum chloride injection in lateral ventricle on serum Gonadoothropines, Testosterone and spermatogenesis.J.Med.Sci..2008; 8 (4) :410-414.
48. Mayyas I, Elbetieha A, Khamas WA. Evaluation of reproductive and fertility toxic potentials of aluminum chloride on adult male mice. Journal of animal and veterinary adnaances.2005;4(2) :224-233.
49. Henschler D. Identification of choline esters in biological material, especially acetylcholine in royal jellyof bee. Hoppe-Seyler's Zeitschrift für physiologische Chemie.1956; 305 (1): 34-41.
50. Muller EE, Nistico G, Scapagnini U. .Neurotransmitters and Anterior Pituitary Function. New York Academic Press.1977.
51. West JB.Best and Taylor’s Physiology basis of Medical Practice 14thed. Williams and Wilking, London.1997; PP: 907-933.
52. Guo C, Huang C, Chen S, Hsu G. Serum and testicular testosterone and nitric oxide products in aluminum-treated mice. Environmental toxicology and pharmacology.2001; 10 (1-2): 53-60.
53. Moselhy WA, Helmy NA, Abdel-Halim BR, Nabil TM, Abdel-Hamid MI. Role of ginger against the reproductive toxicity of aluminium chloride in albino male rats. Reprod Domest Anim.2012; 47(2): p.335.
54. Guo CH, Hsu GSW, Chuang CJ, Chen PC. Aluminum accumulation induced testicular oxidative stress and altered selenium metabolism in mice. Environmental Toxicology and pharmacology.2009; 27: 176- 181.
55. Najafi G, Nejati V, Jalali AS , Zahmatkesh E. Protective role of royal Jelly in oxymetholone-induced oxidative injury in mouse testis. Iranian Journal of Toxicology.2014; 8(25):1073-1080.
56. Schally AV, Pedding JW, Matson HI, Arimura AB. Stimulation of FSH and LH release in vitro by natural and synthetic LH and FSH releasing hormones. Endocrinology.1972; 40:1561-1567.
57. Al-Sanafi A E, Mohssin SA, Abdulla SM. Effect of royal jelly on male infertility. Thi-Qar Medical Journal (TQMJ).2007; 1 (1):1-12.
58. Burimistrova L. Physico-chemical and biological appreciation of drone brood. PhD Ryazan Medical University, Russia.1999; 159pp.
59. Hunt CD, Johnson PE, Herbal JL, Mullen LK. Effect dietary zinc depletion on seminal volume and zinc loss, serum testosterone concentration and sperm morphology in young men. Am.J.Clin.Nutr.1992; 56:148-157.
60. Agrawal A, Gupta S, Sharma RK. Role of oxidative stress in female reproduction. Reprod Bio Endocrinol.2005; 3:28.
61. Cemek M, Aymelek F, Buyukokuroglu ME, Karaca T, Buyukben A, Yilmaz F. Protective potential of Royal Jelly against carbon tetrachloride induced-toxicity and changes in the serum sialic acid levels. Food and Chemical Toxicology.2010; 48: 2827-2832.
62. El-Nekeety AA, El-Kholy W, Abbas N F, Ebaid A, Amra HA, Abdel-Wahhab MA. Efficacy of royal jelly against the oxidative stress of fumonisin in rats. Toxicon.2007; 50: 256-269.
63. Aitken RJ, Clarkson JS, Fishel S. Generation of reactive oxygen species, lipid peroxidation and human sperm function. Biol. Reprod.1989; 40: 183–197.
64. Sanocka D, Kurpisz M. Reactive oxygen species and sperm cell. Reprod Biol Endocrinol.2004; 2: 12.
65. Storey BT. Biochemistry of the induction and prevention of lipoperoxidative damage in human spermatozoa. Mol. Hum. 1997; Reprod., 3: 203-214.
66. Gomez E, Irvine DS, Aitken RJ. Evaluation of a spectrophotometric assay for the measurement of malondialdehyde and 4-hydroxyalkenals in human spermatozoa: relationships with semen quality and sperm function. Int J Androl.1998; 21: 81-84.
67. Cihan Y B, Ozturk A ,Gokalp SS. Protective role of royal Jelly against radiation-induced oxidative stress in rats. International Journal of Hematology and oncology.2013; 23 (2):79-87.
68. Bărnuţiu LI, Mărghitaş LA, Dezmirean DS, Mihai CM, Bobiş O . Chemical composition and antimicrobial activity of royal jelly–Review. Scientific Papers: Animal Science and Biotechnologies.2011; 44 (2): 67-72.
69. Winkler BS, Orselli SM, Rex TS. The redox couple between glutathione, ascorbic acid: a chemical and physiological perspective. Free Radic. Biol. Med. 1994; 17: 333-349.
70. Gou H, Ekusa A, Iwai K, Yonekura M, Takahata Y , Morimatsu F.Royal jelly peptides inhibit lipid peroxidation in in vitro and in vivo. J Nutr Sci Vitaminol.2008; 54:191-195.
71. Kanbur M, Eraslan G, Beyaz L. The effects of royal jelly onliver damage induced by paracetamol in mice. Exp Toxicol Pathol .2009; 61:123-132.
2. Agency for Toxic Substances and Disease Registry (ATSDR). Toxicological Profile for aluminum. Atlanta, Georgia. 2008.
3. Kumar V, Gill KD. Aluminium neurotoxicity: neurobehavioural and oxidative aspects. Archives of Toxicology. 2009; 83: 965-978.
4. Domingo JL. Reproductive and Developmental Toxicity of Aluminum: A Review. Neurotoxicology and Teratology. 1994; 17 (4): 515-521.
5. Mathur N, Pandey G, Jain GC. Male Reproductive Toxicity of Some Selected metals: A review. Journal of Biological sciences. 2010; 10(5):396-204.
6. Pandey G, Jain GC. A review on toxic effects of aluminum exposure on male reproductive system and probable mechanisms of toxicity. International Journal of Toxicology and Applied Pharmacology.2013; 3(3): 48-57.
7. Takenaka T..Chemical composition of royal jelly. Honeybee Sci.1982; 3:69-74.
8. Atshan MH, Yousef JJ. Effect of some products of honey bees in hydatid cysts and some hematological and immunological parameters in Balb/c mice. Magazine of Al-Kufa University for Biology. 2010; (1):49-64.
9. Nagaia T, Mizuho S, Inouec R, Inouec H, Suzuki N. Antioxidative activities of some commercially honeys, royal jelly, and propolis. Food Chemistry. 2001; 75: 237-240.
10. Khattab HAH, Abdallah IZA, Kamel GM.Grape seed extract alleviate reproductive toxicity caused by aluminium chloride in male rats. Journal of American Science.2010; 6(12):1200-1209.
11. Galaly SR, Abdella EM, Mohammed HM, khadrawy S M. Effects of royal jelly on genotoxicity and nephrotoxicity induced by valproic acid in albino mice. Beni-Suef University Journal of Basic and Applied Scinces. 2014; 3 :( 1-15).
12. Ige FS, Achebe ER. The role of Allium cepa on aluminum-induced reproductive dysfunction in experimental male rat models. Journal of human reproductive scince. 2012; 5 (2).
13. Schiller NK, McNamara DB. Balloon catheter vascular injury of the alloxan- induced diabetic rabbit: The role of insulin-like growth factor-1. Molecular and Cellular Biochemistry. 1999; 202:159-167.
14. Silici S, Ekmekcioglu O, Eraslan G, Demirtas A. Antioxidative Effect of royal jelly in cisplatin-induced testes damage. J. Urology.2009; 74(3):545-551.
15. Seed J, Chapin RE, Clegg ED. Methods for assessing sperm motility, morphology and counts in the rat, rabbit and dog: a consensus report. Rep.Toxicol. 1996; 10: 237-244.
16. Blom E. A one-minute live–dead sperm stain by means of eosinnigrosin. J.Fertil. Steril.1950; 1:176–177.
17. Linder RE, Klinefetter GR, Strader LF. Dibromoacetic acid affects reproductive competence and sperm quality in the male rats. Fund. Appl.Toxicol. 1995; 28: 9-17.
18. Amirshahi T, Najafi G, Nejati V. Protective effect of royal jelly on fertility and biochemical parameters in bleomycin-induced male rats. Iran J Reprod Med. 2014; 12 (3):209-216.
19. Zhu YZ, Sun H, Yang Fu , Wang J, Song M, Li M, Li YF, Miao LG. Effects of sub-chronic aluminum chloride on spermatogenesis and testicular enzymatic activity in male rats. Life Sciences. 2014; 102: 36–40.
20. Gutteridge JMC. Lipid peroxidation and antioxidants as biomarkers of tissue damage. Clin. Chem.1995; 14:1819-1828.
21. Steel ROD, Torrie JII. Principles and produces of statistics. New York: Macgraw-till Book Company.1960; Inc. 76.
22. Wyrobek AJ, Bruce WR. Chemical induction of sperm abnormalities in mice. Cell Biol.1975; 72: 4425-4429.
23. Sembulingam K, sembulingam P. Male reproductive system: In Essential of Medical Physiology .3rd Ed. New Delhi: Jaypee brother’s ltd. 2004; p 371-418.
24. Hidaka S, Okamoto Y, Uchiyama S, Nakatsuma A, Hashimoto K, Ohnishi ST , Yamaguchi M. Royal Jelly prevents osteoporosis inrats: beneficial effects in ovaryectomy model and in bone tissue culture model. Evidence-based Complementary and Alternative Medicine.2006; 3 (3): 339-348
25. Menkovska M. The Newest Experience with Effervescent Tablets Containing Royal Jelly as Functional Food on Packing, Dosage and Synergistic Action in Prevention, Prophylaxis and Healing . Journal of Food Processing and Technology.2013; 4(10).
26. Robak – cholubek D, Jakiel G. Zinc level in seminal plasma and sperm density. Gin.Pol. 1998; 69(6): 490-493.
27. Dawson EB, Ritter S, Harris WA, Evans DR, Powell LC. Comparison of sperm viability with seminal plasma metal levels. Biol. Trace Elem. Res.1998; 64: 215–223.
28. Zatta P, Lain E, Cagnolini C . Effects of aluminum on activity of Krebs cycle enzymes and glutamate dehydrogenase in rat brain homogenate. Eur. J. Biochem.2000; 267: 3049-3055.
29. Yousef MI, Kamel KI, El-Guendi MI, El-Demerdash FM. An in vitro study on reproductive toxicity of aluminium chloride on rabbit sperm: the protective role of some antioxidants. Toxicology. 2007; 239: 213-223.
30. Bidlingmaier F, Helmuth GD, Wolfgana E, Ursula K , Dietrch K. Testosterone and androstenedione concentrations in human testis and epididymis during the first two years of life. Journal of Clinical Endocrinology and Metabolism.1983; 57(2).
31. Hassan AA. Effect of royal jelly on sexual efficiency in adult male rats. Iraqi Journal of Veterinary Sciences.2009; 23 (2):155-160.
32. Elnagar S A. Royal jelly counteracts bucks’ “summer infertility” Animal Reproduction Science. 2010; 121: 174-180.
33. Moradi AR, Malekinejad H, Farrokhi-Ardabili F, Bernousi I. Royal Jelly improves the sperm parameters of ram semen during liquid storage and serves as an antioxidant source. Small ruminant research.2013; 113: 346-352.
34. Zahmatkesh E, Najafi G, Nejati V, Heidari R. Protective effect of royal jelly on the sperm parameters and testosterone level and lipid peroxidation in adult mice treated with oxymetholone. Avicenna Journal of Phytomedicine.2013; 4(1):43-52.
35. Aitken RJ, Baker MA, Sawyer D. Oxidative stress in the male germ line and its role in the etiology of male infertility and genetic disease, Reprod. Biomed.2003; 7: 65-70.
36. Abdul-Rasoul E M, Hassan N A, Al-Mallah K H. Effect of aluminium chloride on sexual efficiency in adult male rats. J. Edu. Sci.2009; 22 (4): 27-44.
37. Ebisch IMW, Pierik FH, Jong FH, Thomas CMG, Steeger-Theunissen RPM. Does folic acid and zinc sulphate intervention affect endocrine parameters and sperm characteristics in men? Intern J Andro.2006; 29(2):339-345.
38. Lenzi1 a, Picardo M, Gandini L, Dondero F. Lipids of the sperm plasma membrane: from polyunsaturated fatty acids considered as markers of sperm function to possible scavenger therapy. Human Reproduction Update.1996; 2: 246–256.
39. Aitken RJ, Koppers AJ. Apoptosis and DNA damage in human spermatozoa. Asian J. Androl.2011; 13: 36–42.
40. Shostia AM. Role of reactive oxygen species in regulation of spermatogenesis and fertilization in mammals. Ukr. Biokhim. Zh.2009; 81: 14–22.
41. Kim JG, Parthasarathy S. Oxidation and the spermatozoa. Semen. Reprod. Endocrinol.1998; 16: 235–239.
42. Graham J. (Ed.). The Hive and the Honey Bee. Dadant and Sons, Inc., Hamilton, IL.U.S.A.1992; 1324 pp.
43. Inoue S, Koya-Miyata S, Ushio S, Iwaki K, Ikeda M, and Kurimoto M. Royal Jelly prolongs the life span of C3H/HeJ mice: correlation with reduced DNA damage. Exp.Gerontol.2003; 38(9):965-969.
44. Cavusoglu K, Yapar K , Yalcin E. Royal jelly (honey bee) is a potential antioxidant against cadmium-induced genotoxicity and oxidative stress in albino mice.2009; J Med Food.,12(6).
45. Liu JY, stemmer KL. Interaction between aluminum and aic or copper and its effects on the pituitary-testicular axis. II. Testicular enzyme and serum gonadotropin assay. Biomed. Environ.Sci.1990; 3 (11).
46. Barrett K E, Boitano S, Barman S M , Brooks H L. Ganong's Review of Medical Physiology. 23th Edn. . New York: McGraw .Hill.2010.
47. Shahraki MR, Palan Mony EY, Zahedi Asil S, Sarkaki AR, Sarkaki AR. Effect of aluminum chloride injection in lateral ventricle on serum Gonadoothropines, Testosterone and spermatogenesis.J.Med.Sci..2008; 8 (4) :410-414.
48. Mayyas I, Elbetieha A, Khamas WA. Evaluation of reproductive and fertility toxic potentials of aluminum chloride on adult male mice. Journal of animal and veterinary adnaances.2005;4(2) :224-233.
49. Henschler D. Identification of choline esters in biological material, especially acetylcholine in royal jellyof bee. Hoppe-Seyler's Zeitschrift für physiologische Chemie.1956; 305 (1): 34-41.
50. Muller EE, Nistico G, Scapagnini U. .Neurotransmitters and Anterior Pituitary Function. New York Academic Press.1977.
51. West JB.Best and Taylor’s Physiology basis of Medical Practice 14thed. Williams and Wilking, London.1997; PP: 907-933.
52. Guo C, Huang C, Chen S, Hsu G. Serum and testicular testosterone and nitric oxide products in aluminum-treated mice. Environmental toxicology and pharmacology.2001; 10 (1-2): 53-60.
53. Moselhy WA, Helmy NA, Abdel-Halim BR, Nabil TM, Abdel-Hamid MI. Role of ginger against the reproductive toxicity of aluminium chloride in albino male rats. Reprod Domest Anim.2012; 47(2): p.335.
54. Guo CH, Hsu GSW, Chuang CJ, Chen PC. Aluminum accumulation induced testicular oxidative stress and altered selenium metabolism in mice. Environmental Toxicology and pharmacology.2009; 27: 176- 181.
55. Najafi G, Nejati V, Jalali AS , Zahmatkesh E. Protective role of royal Jelly in oxymetholone-induced oxidative injury in mouse testis. Iranian Journal of Toxicology.2014; 8(25):1073-1080.
56. Schally AV, Pedding JW, Matson HI, Arimura AB. Stimulation of FSH and LH release in vitro by natural and synthetic LH and FSH releasing hormones. Endocrinology.1972; 40:1561-1567.
57. Al-Sanafi A E, Mohssin SA, Abdulla SM. Effect of royal jelly on male infertility. Thi-Qar Medical Journal (TQMJ).2007; 1 (1):1-12.
58. Burimistrova L. Physico-chemical and biological appreciation of drone brood. PhD Ryazan Medical University, Russia.1999; 159pp.
59. Hunt CD, Johnson PE, Herbal JL, Mullen LK. Effect dietary zinc depletion on seminal volume and zinc loss, serum testosterone concentration and sperm morphology in young men. Am.J.Clin.Nutr.1992; 56:148-157.
60. Agrawal A, Gupta S, Sharma RK. Role of oxidative stress in female reproduction. Reprod Bio Endocrinol.2005; 3:28.
61. Cemek M, Aymelek F, Buyukokuroglu ME, Karaca T, Buyukben A, Yilmaz F. Protective potential of Royal Jelly against carbon tetrachloride induced-toxicity and changes in the serum sialic acid levels. Food and Chemical Toxicology.2010; 48: 2827-2832.
62. El-Nekeety AA, El-Kholy W, Abbas N F, Ebaid A, Amra HA, Abdel-Wahhab MA. Efficacy of royal jelly against the oxidative stress of fumonisin in rats. Toxicon.2007; 50: 256-269.
63. Aitken RJ, Clarkson JS, Fishel S. Generation of reactive oxygen species, lipid peroxidation and human sperm function. Biol. Reprod.1989; 40: 183–197.
64. Sanocka D, Kurpisz M. Reactive oxygen species and sperm cell. Reprod Biol Endocrinol.2004; 2: 12.
65. Storey BT. Biochemistry of the induction and prevention of lipoperoxidative damage in human spermatozoa. Mol. Hum. 1997; Reprod., 3: 203-214.
66. Gomez E, Irvine DS, Aitken RJ. Evaluation of a spectrophotometric assay for the measurement of malondialdehyde and 4-hydroxyalkenals in human spermatozoa: relationships with semen quality and sperm function. Int J Androl.1998; 21: 81-84.
67. Cihan Y B, Ozturk A ,Gokalp SS. Protective role of royal Jelly against radiation-induced oxidative stress in rats. International Journal of Hematology and oncology.2013; 23 (2):79-87.
68. Bărnuţiu LI, Mărghitaş LA, Dezmirean DS, Mihai CM, Bobiş O . Chemical composition and antimicrobial activity of royal jelly–Review. Scientific Papers: Animal Science and Biotechnologies.2011; 44 (2): 67-72.
69. Winkler BS, Orselli SM, Rex TS. The redox couple between glutathione, ascorbic acid: a chemical and physiological perspective. Free Radic. Biol. Med. 1994; 17: 333-349.
70. Gou H, Ekusa A, Iwai K, Yonekura M, Takahata Y , Morimatsu F.Royal jelly peptides inhibit lipid peroxidation in in vitro and in vivo. J Nutr Sci Vitaminol.2008; 54:191-195.
71. Kanbur M, Eraslan G, Beyaz L. The effects of royal jelly onliver damage induced by paracetamol in mice. Exp Toxicol Pathol .2009; 61:123-132.
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Published
2020-04-08
How to Cite
Abbas Hadi, A.-H. ., & Deaibil, H. B. . (2020). Effect of Royal Jelly on Sperm Parameters in Aluminum-Treated Male Rats. The Journal of Applied Tissue Engineering, 7(1), 8–17. https://doi.org/10.22034/JATE.2020.36
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