The Use of Exosomes as Carriers for Inhibiting Breast Cancer through a Chitosan Base Hydrogel Scaffold
DOI:
https://doi.org/10.22034/JATE.2019.35Keywords:
Exosomes, Chitosan, Cancer, HydrogelAbstract
Extracellular vesicles (EVs) are secreted from the cells to the extracellular space, which have the role of cellular communication both topically and systemically. EVs are divided into three categories: exosomes, micro vesicles and apoptotic body. Exosome particles are in the size of 30 to 100 nm. Exosomes, according to studies, include miRNAs that play a role in their biological effects and, after exosome entry into the target cell, has its own effects. On the other hand, exosomes can be used as drug carriers. Hydrogel scaffolds can be used as drug delivery systems for transferring cells and various factors. This hypothesis was designed with the aim of using a chitosan-based hydroxyl delivery system for the transfer of exosomes of anticancer drug carrier to inhibit breast cancer cells in mice.
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