The Use of Exosomes as Carriers for Inhibiting Breast Cancer through a Chitosan Base Hydrogel Scaffold
DOI:
https://doi.org/10.22034/JATE.2019.35Keywords:
Exosomes, Chitosan, Cancer, HydrogelAbstract
Extracellular vesicles (EVs) are secreted from the cells to the extracellular space, which have the role of cellular communication both topically and systemically. EVs are divided into three categories: exosomes, micro vesicles and apoptotic body. Exosome particles are in the size of 30 to 100 nm. Exosomes, according to studies, include miRNAs that play a role in their biological effects and, after exosome entry into the target cell, has its own effects. On the other hand, exosomes can be used as drug carriers. Hydrogel scaffolds can be used as drug delivery systems for transferring cells and various factors. This hypothesis was designed with the aim of using a chitosan-based hydroxyl delivery system for the transfer of exosomes of anticancer drug carrier to inhibit breast cancer cells in mice.
References
2. Khoee S, Kardani M. Hydrogels as Controlled Drug Delivery Carriers. Polymerization; 2013.
3. Park JH, Saravanakumar G, Kim K, Kwon IC. Targeted delivery of low molecular drugs using chitosan and its derivatives. Advanced drug delivery reviews. 2010;62(1):28-41.
4. Bhattarai N, Gunn J, Zhang M. Chitosan-based hydrogels for controlled, localized drug delivery. Advanced drug delivery reviews. 2010;62(1):83-99.
5. O'Loghlen A. Role for extracellular vesicles in the tumour microenvironment. Philosophical Transactions of the Royal Society B: Biological Sciences. 2017;373(1737):20160488.
6. Yang C, Robbins PD. The roles of tumor-derived exosomes in cancer pathogenesis. Clinical and Developmental Immunology. 2011;2011.
7. Kalluri R. The biology and function of exosomes in cancer. The Journal of clinical investigation. 2016;126(4):1208-15.
8. Sun D, Zhuang X, Xiang X, Liu Y, Zhang S, Liu C, et al. A novel nanoparticle drug delivery system: the anti-inflammatory activity of curcumin is enhanced when encapsulated in exosomes. Molecular Therapy. 2010;18(9):1606-14.
9. Kim MS, Haney MJ, Zhao Y, Mahajan V, Deygen I, Klyachko NL, et al. Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells. Nanomedicine: Nanotechnology, Biology and Medicine. 2016;12(3):655-64.
10. Soleimani M, Nadri S, Izadpanah R. Isolation of mesenchymal stem cells from mouse bone marrow: frequent medium change method. Tehran University Medical Journal TUMS Publications. 2008;66(4):229-36.
11. Nojehdehi S, Hashemi SM, Hesampour A. Isolation and characterization of exosomes separated from stem cells by ultra-centrifuge method. Research in Medicine. 2017;73(4):244-50.
12. Shi Q, Qian Z, Liu D, Sun J, Wang X, Liu H, et al. GMSC-Derived Exosomes Combined with a Chitosan/Silk Hydrogel Sponge Accelerates Wound Healing in a Diabetic Rat Skin Defect Model. Frontiers in physiology. 2017;8:904.
13. Haddad-Mashadrizeh A, Matin MM, Bahrami AR, Edalatmanesh MA, Naderi-Meshkin H, Mousavi S, et al. Cytotoxicity and biocompatibility evaluation of chitosan-beta glycerol phosphate-hydroxyethyl cellulose hydrogel on adult rat liver for cell-based therapeutic applications. International Journal of Biomedical Engineering and Technology. 2013;12(3):228-39.