A Review on Inner Ear Tissue Engineering
DOI:
https://doi.org/10.22034/JATE.2018.30Keywords:
Tissue engineering, Inner ear, Hearing lossAbstract
Ear defects and hearing loss are still one of the challenging problems in medicine. Tissue engineering approaches are considered as promising and efficient tools for such problems. Tissue engineering is considered a newly appearing biomedical technology, which could repair and regenerate inadequate or injured tissues. It utilizes the principles from the areas of cell biology and transplantation, materials science and engineering to treat or replace injured tissues. Different types of cell sources, growth factors or signals, materials or scaffolds and different methods have been studied to repair or replace different parts of ear and restore its function and hearing. In this review we present recent such elements studied or proposed for inner ear reconstruction.
References
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2. Staudenmaier R, Mandlik V, Schurr C, Burghartz M, Hauber K, Meier G, et al. Customized tissue engineering for ear reconstruction. Aesthetics and Functionality in Ear Reconstruction: Karger Publishers; 2010. p. 120-31.
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6. Martinez-Monedero R, Edge AS. Stem cells for the replacement of inner ear neurons and hair cells. International Journal of Developmental Biology. 2007;51(6/7):655.
7. Ahn K, Jeon S, Jung J, Kim Y, Kang J. Isolation of embryonic stem cells from enhanced green fluorescent protein-transgenic mouse and their survival in the cochlea after allotransplantation. Cytotherapy. 2008;10(7):759-69.
8. Altschuler RA, O’Shea KS, Miller JM. Stem cell transplantation for auditory nerve replacement. Hearing research. 2008;242(1):110-6.
9. Coleman B, Hardman J, Coco A, Epp S, De Silva M, Crook J, et al. Fate of embryonic stem cells transplanted into the deafened mammalian cochlea. Cell transplantation. 2006;15(5):369.
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11. Lang H, Schulte BA, Goddard JC, Hedrick M, Schulte JB, Wei L, et al. Transplantation of mouse embryonic stem cells into the cochlea of an auditory-neuropathy animal model: effects of timing after injury. Journal of the Association for Research in Otolaryngology. 2008;9(2):225-40.
12. Okano T, Nakagawa T, Endo T, Kim T-S, Kita T, Tamura T, et al. Engraftment of embryonic stem cell-derived neurons into the cochlear modiolus. Neuroreport. 2005;16(17):1919-22.
13. Praetorius M, Vicario I, Schimmang T. Efficient transfer of embryonic stem cells into the cochlea via a non-invasive vestibular route. Acta oto-laryngologica. 2008;128(7):720-3.
14. Regala C, Duan M, Zou J, Salminen M, Olivius P. Xenografted fetal dorsal root ganglion, embryonic stem cell and adult neural stem cell survival following implantation into the adult vestibulocochlear nerve. Experimental neurology. 2005;193(2):326-33.
15. Reyes JH, O'Shea KS, Wys NL, Velkey JM, Prieskorn DM, Wesolowski K, et al. Glutamatergic neuronal differentiation of mouse embryonic stem cells after transient expression of neurogenin 1 and treatment with BDNF and GDNF: in vitro and in vivo studies. The Journal of Neuroscience. 2008;28(48):12622-31.
16. Sekiya T, Kojima K, Matsumoto M, Kim T-S, Tamura T, Ito J. Cell transplantation to the auditory nerve and cochlear duct. Experimental neurology. 2006;198(1):12-24.
17. Shi F, Corrales CE, Liberman MC, Edge AS. BMP4 induction of sensory neurons from human embryonic stem cells and reinnervation of sensory epithelium. European Journal of Neuroscience. 2007;26(11):3016-23.
18. Corrales CE, Pan L, Li H, Liberman MC, Heller S, Edge AS. Engraftment and differentiation of embryonic stem cell–derived neural progenitor cells in the cochlear nerve trunk: Growth of processes into the organ of corti. Journal of neurobiology. 2006;66(13):1489-500.
19. Ulfendahl M, Hu Z, Olivius P, Duan M, Wei D. A cell therapy approach to substitute neural elements in the inner ear. Physiology & behavior. 2007;92(1):75-9.
20. Nakagawa T, Ito J. Cell therapy for inner ear diseases. Current pharmaceutical design. 2005;11(9):1203-7.
21. Oshima K, Suchert S, Blevins NH, Heller S. Curing hearing loss: Patient expectations, health care practitioners, and basic science. Journal of communication disorders. 2010;43(4):311-8.
22. Oshima K, Shin K, Diensthuber M, Peng AW, Ricci AJ, Heller S. Mechanosensitive hair cell-like cells from embryonic and induced pluripotent stem cells. cell. 2010;141(4):704-16.
23. Martinez-Monedero R, Edge AS. Stem cells for the replacement of inner ear neurons and hair cells. International Journal of Developmental Biology. 2007;51(6-7):655-61.
24. Rivolta MN, Li H, Heller S. Generation of inner ear cell types from embryonic stem cells. Embryonic Stem Cell Protocols: Volume 2: Differentiation Models. 2006:71-92.
25. De Coppi P, Bartsch G, Siddiqui MM, Xu T, Santos CC, Perin L, et al. Isolation of amniotic stem cell lines with potential for therapy. Nature biotechnology. 2007;25(1):100-6.
26. Donaldson AE, Cai J, Yang M, Iacovitti L. Human amniotic fluid stem cells do not differentiate into dopamine neurons in vitro or after transplantation in vivo. Stem cells and development. 2009;18(7):1003-12.
27. Prusa A-R, Marton E, Rosner M, Bettelheim D, Lubec G, Pollack A, et al. Neurogenic cells in human amniotic fluid. American journal of obstetrics and gynecology. 2004;191(1):309-14.
28. Zong L, Chen K, Zhou W, Jiang D, Sun L, Zhang X, et al. Inner ear stem cells derived feeder layer promote directional differentiation of amniotic fluid stem cells into functional neurons. Hearing research. 2014;316:57-64.
29. Uccelli A, Moretta L, Pistoia V. Mesenchymal stem cells in health and disease. Nature Reviews Immunology. 2008;8(9):726-36.
30. Ohtaki H, Ylostalo JH, Foraker JE, Robinson AP, Reger RL, Shioda S, et al. Stem/progenitor cells from bone marrow decrease neuronal death in global ischemia by modulation of inflammatory/immune responses. Proceedings of the National Academy of Sciences. 2008;105(38):14638-43.
31. Matsuoka AJ, Kondo T, Miyamoto RT, Hashino E. In Vivo and In Vitro Characterization of Bone Marrow‐Derived Stem Cells in the Cochlea. The Laryngoscope. 2006;116(8):1363-7.
32. Jeon S-J, Oshima K, Heller S, Edge AS. Bone marrow mesenchymal stem cells are progenitors in vitro for inner ear hair cells. Molecular and Cellular Neuroscience. 2007;34(1):59-68.
33. Fu Y, Wang S, Liu Y, Wang J, Wang G, Chen Q, et al. Study on neural stem cell transplantation into natural rat cochlea via round window. American journal of otolaryngology. 2009;30(1):8-16.
34. Hu Z, Wei D, Johansson CB, Holmström N, Duan M, Frisén J, et al. Survival and neural differentiation of adult neural stem cells transplanted into the mature inner ear. Experimental cell research. 2005;302(1):40-7.
35. Iguchi F, Nakagawa T, Tateya I, Kim TS, Endo T, Taniguchi Z, et al. Trophic support of mouse inner ear by neural stem cell transplantation. Neuroreport. 2003;14(1):77-80.
36. Tamura T, Nakagawa T, Iguchi F, Tateya I, Endo T, Kim T, et al. Transplantation of neural stem cells into the modiolus of mouse cochleae injured by cisplatin. ACTA OTOLARYNGOLOGICA SUPPLEMENTUM. 2004:65-8.
37. Tateya I, Nakagawa T, Iguchi F, Kim TS, Endo T, Yamada S, et al. Fate of neural stem cells grafted into injured inner ears of mice. Neuroreport. 2003;14(13):1677-81.
38. Chen W, Jongkamonwiwat N, Abbas L, Eshtan SJ, Johnson SL, Kuhn S, et al. Restoration of auditory evoked responses by human ES-cell-derived otic progenitors. Nature. 2012;490(7419):278-82.
39. Parker MA, Corliss DA, Gray B, Anderson JK, Bobbin RP, Snyder EY, et al. Neural stem cells injected into the sound-damaged cochlea migrate throughout the cochlea and express markers of hair cells, supporting cells, and spiral ganglion cells. Hearing research. 2007;232(1):29-43.
40. Wang Y, Dong M. In vitro induction and differentiation of newborn guinea pig hippocampus neural stem cells into cells resembling inner hair cells, using artificial perilymph. The Journal of Laryngology & Otology. 2011;125(08):771-5.
41. Okano T, Xuan S, Kelley MW. Insulin-like growth factor signaling regulates the timing of sensory cell differentiation in the mouse cochlea. Journal of Neuroscience. 2011;31(49):18104-18.
42. Lee KY, Nakagawa T, Okano T, Hori R, Ono K, Tabata Y, et al. Novel therapy for hearing loss: delivery of insulin-like growth factor 1 to the cochlea using gelatin hydrogel. Otology & Neurotology. 2007;28(7):976-81.
43. Angunsri N, Taura A, Nakagawa T, Hayashi Y, Kitajiri S-i, Omi E, et al. Insulin-like growth factor 1 protects vestibular hair cells from aminoglycosides. Neuroreport. 2011;22(1):38-43.
44. Hayashi Y, Yamamoto N, Nakagawa T, Ito J. Insulin-like growth factor 1 inhibits hair cell apoptosis and promotes the cell cycle of supporting cells by activating different downstream cascades after pharmacological hair cell injury in neonatal mice. Molecular and Cellular Neuroscience. 2013;56:29-38.
45. Fariñas I, Jones KR, Tessarollo L, Vigers AJ, Huang E, Kirstein M, et al. Spatial shaping of cochlear innervation by temporally regulated neurotrophin expression. Journal of Neuroscience. 2001;21(16):6170-80.
46. Lidian A, Stenkvist–Asplund M, Linder B, Anniko M, Nordang L. Early hearing protection by brain-derived neurotrophic factor. Acta oto-laryngologica. 2012;133(1):12-21.
47. Ruan RS, Leong SK, Mark I, Yeoh KH. Effects of BDNF and NT‐3 on hair cell survival in guinea pig cochlea damaged by kanamycin treatment. Neuroreport. 1999;10(10):2067-71.
48. Yang T, Kersigo J, Jahan I, Pan N, Fritzsch B. The molecular basis of making spiral ganglion neurons and connecting them to hair cells of the organ of Corti. Hearing research. 2011;278(1):21-33.
49. Rubel EW, Fritzsch B. Auditory system development: primary auditory neurons and their targets. Annual review of neuroscience. 2002;25(1):51-101.
50. Jahan I, Pan N, Kersigo J, Fritzsch B. Beyond generalized hair cells: molecular cues for hair cell types. Hearing research. 2013;297:30-41.
51. Kesser B, Lalwani A. Gene therapy and stem cell transplantation: strategies for hearing restoration. Gene Therapy of Cochlear Deafness: Karger Publishers; 2009. p. 64-86.
52. Wise AK, Tu T, Atkinson PJ, Flynn BO, Sgro BE, Hume C, et al. The effect of deafness duration on neurotrophin gene therapy for spiral ganglion neuron protection. Hearing research. 2011;278(1):69-76.
53. Drury JL, Mooney DJ. Hydrogels for tissue engineering: scaffold design variables and applications. Biomaterials. 2003;24(24):4337-51.
54. Endo T, Nakagawa T, Kita T, Iguchi F, Kim TS, Tamura T, et al. Novel strategy for treatment of inner ears using a biodegradable gel. The Laryngoscope. 2005;115(11):2016-20.
55. Peterson DR, Bronzino JD. Biomechanics: principles and applications: CRC press; 2007.
56. Mellott AJ, Shinogle HE, Nelson-Brantley JG, Detamore MS, Staecker H. Exploiting decellularized cochleae as scaffolds for inner ear tissue engineering. Stem cell research & therapy. 2017;8(1):41.
2. Staudenmaier R, Mandlik V, Schurr C, Burghartz M, Hauber K, Meier G, et al. Customized tissue engineering for ear reconstruction. Aesthetics and Functionality in Ear Reconstruction: Karger Publishers; 2010. p. 120-31.
3. Sterodimas A, de Faria J, Correa WE, Pitanguy I. Tissue engineering and auricular reconstruction: a review. Journal of Plastic, Reconstructive & Aesthetic Surgery. 2009;62(4):447-52.
4. Senn P, Heller S. [Stem-cell-based approaches for treating inner ear diseases]. Hno. 2008;56(1):21-6.
5. Pauley S, Kopecky B, Beisel K, Soukup G, Fritzsch B. Stem cells and molecular strategies to restore hearing. Panminerva medica. 2008;50(1):41.
6. Martinez-Monedero R, Edge AS. Stem cells for the replacement of inner ear neurons and hair cells. International Journal of Developmental Biology. 2007;51(6/7):655.
7. Ahn K, Jeon S, Jung J, Kim Y, Kang J. Isolation of embryonic stem cells from enhanced green fluorescent protein-transgenic mouse and their survival in the cochlea after allotransplantation. Cytotherapy. 2008;10(7):759-69.
8. Altschuler RA, O’Shea KS, Miller JM. Stem cell transplantation for auditory nerve replacement. Hearing research. 2008;242(1):110-6.
9. Coleman B, Hardman J, Coco A, Epp S, De Silva M, Crook J, et al. Fate of embryonic stem cells transplanted into the deafened mammalian cochlea. Cell transplantation. 2006;15(5):369.
10. Hu Z, Ulfendahl M, Olivius NP. Central migration of neuronal tissue and embryonic stem cells following transplantation along the adult auditory nerve. Brain research. 2004;1026(1):68-73.
11. Lang H, Schulte BA, Goddard JC, Hedrick M, Schulte JB, Wei L, et al. Transplantation of mouse embryonic stem cells into the cochlea of an auditory-neuropathy animal model: effects of timing after injury. Journal of the Association for Research in Otolaryngology. 2008;9(2):225-40.
12. Okano T, Nakagawa T, Endo T, Kim T-S, Kita T, Tamura T, et al. Engraftment of embryonic stem cell-derived neurons into the cochlear modiolus. Neuroreport. 2005;16(17):1919-22.
13. Praetorius M, Vicario I, Schimmang T. Efficient transfer of embryonic stem cells into the cochlea via a non-invasive vestibular route. Acta oto-laryngologica. 2008;128(7):720-3.
14. Regala C, Duan M, Zou J, Salminen M, Olivius P. Xenografted fetal dorsal root ganglion, embryonic stem cell and adult neural stem cell survival following implantation into the adult vestibulocochlear nerve. Experimental neurology. 2005;193(2):326-33.
15. Reyes JH, O'Shea KS, Wys NL, Velkey JM, Prieskorn DM, Wesolowski K, et al. Glutamatergic neuronal differentiation of mouse embryonic stem cells after transient expression of neurogenin 1 and treatment with BDNF and GDNF: in vitro and in vivo studies. The Journal of Neuroscience. 2008;28(48):12622-31.
16. Sekiya T, Kojima K, Matsumoto M, Kim T-S, Tamura T, Ito J. Cell transplantation to the auditory nerve and cochlear duct. Experimental neurology. 2006;198(1):12-24.
17. Shi F, Corrales CE, Liberman MC, Edge AS. BMP4 induction of sensory neurons from human embryonic stem cells and reinnervation of sensory epithelium. European Journal of Neuroscience. 2007;26(11):3016-23.
18. Corrales CE, Pan L, Li H, Liberman MC, Heller S, Edge AS. Engraftment and differentiation of embryonic stem cell–derived neural progenitor cells in the cochlear nerve trunk: Growth of processes into the organ of corti. Journal of neurobiology. 2006;66(13):1489-500.
19. Ulfendahl M, Hu Z, Olivius P, Duan M, Wei D. A cell therapy approach to substitute neural elements in the inner ear. Physiology & behavior. 2007;92(1):75-9.
20. Nakagawa T, Ito J. Cell therapy for inner ear diseases. Current pharmaceutical design. 2005;11(9):1203-7.
21. Oshima K, Suchert S, Blevins NH, Heller S. Curing hearing loss: Patient expectations, health care practitioners, and basic science. Journal of communication disorders. 2010;43(4):311-8.
22. Oshima K, Shin K, Diensthuber M, Peng AW, Ricci AJ, Heller S. Mechanosensitive hair cell-like cells from embryonic and induced pluripotent stem cells. cell. 2010;141(4):704-16.
23. Martinez-Monedero R, Edge AS. Stem cells for the replacement of inner ear neurons and hair cells. International Journal of Developmental Biology. 2007;51(6-7):655-61.
24. Rivolta MN, Li H, Heller S. Generation of inner ear cell types from embryonic stem cells. Embryonic Stem Cell Protocols: Volume 2: Differentiation Models. 2006:71-92.
25. De Coppi P, Bartsch G, Siddiqui MM, Xu T, Santos CC, Perin L, et al. Isolation of amniotic stem cell lines with potential for therapy. Nature biotechnology. 2007;25(1):100-6.
26. Donaldson AE, Cai J, Yang M, Iacovitti L. Human amniotic fluid stem cells do not differentiate into dopamine neurons in vitro or after transplantation in vivo. Stem cells and development. 2009;18(7):1003-12.
27. Prusa A-R, Marton E, Rosner M, Bettelheim D, Lubec G, Pollack A, et al. Neurogenic cells in human amniotic fluid. American journal of obstetrics and gynecology. 2004;191(1):309-14.
28. Zong L, Chen K, Zhou W, Jiang D, Sun L, Zhang X, et al. Inner ear stem cells derived feeder layer promote directional differentiation of amniotic fluid stem cells into functional neurons. Hearing research. 2014;316:57-64.
29. Uccelli A, Moretta L, Pistoia V. Mesenchymal stem cells in health and disease. Nature Reviews Immunology. 2008;8(9):726-36.
30. Ohtaki H, Ylostalo JH, Foraker JE, Robinson AP, Reger RL, Shioda S, et al. Stem/progenitor cells from bone marrow decrease neuronal death in global ischemia by modulation of inflammatory/immune responses. Proceedings of the National Academy of Sciences. 2008;105(38):14638-43.
31. Matsuoka AJ, Kondo T, Miyamoto RT, Hashino E. In Vivo and In Vitro Characterization of Bone Marrow‐Derived Stem Cells in the Cochlea. The Laryngoscope. 2006;116(8):1363-7.
32. Jeon S-J, Oshima K, Heller S, Edge AS. Bone marrow mesenchymal stem cells are progenitors in vitro for inner ear hair cells. Molecular and Cellular Neuroscience. 2007;34(1):59-68.
33. Fu Y, Wang S, Liu Y, Wang J, Wang G, Chen Q, et al. Study on neural stem cell transplantation into natural rat cochlea via round window. American journal of otolaryngology. 2009;30(1):8-16.
34. Hu Z, Wei D, Johansson CB, Holmström N, Duan M, Frisén J, et al. Survival and neural differentiation of adult neural stem cells transplanted into the mature inner ear. Experimental cell research. 2005;302(1):40-7.
35. Iguchi F, Nakagawa T, Tateya I, Kim TS, Endo T, Taniguchi Z, et al. Trophic support of mouse inner ear by neural stem cell transplantation. Neuroreport. 2003;14(1):77-80.
36. Tamura T, Nakagawa T, Iguchi F, Tateya I, Endo T, Kim T, et al. Transplantation of neural stem cells into the modiolus of mouse cochleae injured by cisplatin. ACTA OTOLARYNGOLOGICA SUPPLEMENTUM. 2004:65-8.
37. Tateya I, Nakagawa T, Iguchi F, Kim TS, Endo T, Yamada S, et al. Fate of neural stem cells grafted into injured inner ears of mice. Neuroreport. 2003;14(13):1677-81.
38. Chen W, Jongkamonwiwat N, Abbas L, Eshtan SJ, Johnson SL, Kuhn S, et al. Restoration of auditory evoked responses by human ES-cell-derived otic progenitors. Nature. 2012;490(7419):278-82.
39. Parker MA, Corliss DA, Gray B, Anderson JK, Bobbin RP, Snyder EY, et al. Neural stem cells injected into the sound-damaged cochlea migrate throughout the cochlea and express markers of hair cells, supporting cells, and spiral ganglion cells. Hearing research. 2007;232(1):29-43.
40. Wang Y, Dong M. In vitro induction and differentiation of newborn guinea pig hippocampus neural stem cells into cells resembling inner hair cells, using artificial perilymph. The Journal of Laryngology & Otology. 2011;125(08):771-5.
41. Okano T, Xuan S, Kelley MW. Insulin-like growth factor signaling regulates the timing of sensory cell differentiation in the mouse cochlea. Journal of Neuroscience. 2011;31(49):18104-18.
42. Lee KY, Nakagawa T, Okano T, Hori R, Ono K, Tabata Y, et al. Novel therapy for hearing loss: delivery of insulin-like growth factor 1 to the cochlea using gelatin hydrogel. Otology & Neurotology. 2007;28(7):976-81.
43. Angunsri N, Taura A, Nakagawa T, Hayashi Y, Kitajiri S-i, Omi E, et al. Insulin-like growth factor 1 protects vestibular hair cells from aminoglycosides. Neuroreport. 2011;22(1):38-43.
44. Hayashi Y, Yamamoto N, Nakagawa T, Ito J. Insulin-like growth factor 1 inhibits hair cell apoptosis and promotes the cell cycle of supporting cells by activating different downstream cascades after pharmacological hair cell injury in neonatal mice. Molecular and Cellular Neuroscience. 2013;56:29-38.
45. Fariñas I, Jones KR, Tessarollo L, Vigers AJ, Huang E, Kirstein M, et al. Spatial shaping of cochlear innervation by temporally regulated neurotrophin expression. Journal of Neuroscience. 2001;21(16):6170-80.
46. Lidian A, Stenkvist–Asplund M, Linder B, Anniko M, Nordang L. Early hearing protection by brain-derived neurotrophic factor. Acta oto-laryngologica. 2012;133(1):12-21.
47. Ruan RS, Leong SK, Mark I, Yeoh KH. Effects of BDNF and NT‐3 on hair cell survival in guinea pig cochlea damaged by kanamycin treatment. Neuroreport. 1999;10(10):2067-71.
48. Yang T, Kersigo J, Jahan I, Pan N, Fritzsch B. The molecular basis of making spiral ganglion neurons and connecting them to hair cells of the organ of Corti. Hearing research. 2011;278(1):21-33.
49. Rubel EW, Fritzsch B. Auditory system development: primary auditory neurons and their targets. Annual review of neuroscience. 2002;25(1):51-101.
50. Jahan I, Pan N, Kersigo J, Fritzsch B. Beyond generalized hair cells: molecular cues for hair cell types. Hearing research. 2013;297:30-41.
51. Kesser B, Lalwani A. Gene therapy and stem cell transplantation: strategies for hearing restoration. Gene Therapy of Cochlear Deafness: Karger Publishers; 2009. p. 64-86.
52. Wise AK, Tu T, Atkinson PJ, Flynn BO, Sgro BE, Hume C, et al. The effect of deafness duration on neurotrophin gene therapy for spiral ganglion neuron protection. Hearing research. 2011;278(1):69-76.
53. Drury JL, Mooney DJ. Hydrogels for tissue engineering: scaffold design variables and applications. Biomaterials. 2003;24(24):4337-51.
54. Endo T, Nakagawa T, Kita T, Iguchi F, Kim TS, Tamura T, et al. Novel strategy for treatment of inner ears using a biodegradable gel. The Laryngoscope. 2005;115(11):2016-20.
55. Peterson DR, Bronzino JD. Biomechanics: principles and applications: CRC press; 2007.
56. Mellott AJ, Shinogle HE, Nelson-Brantley JG, Detamore MS, Staecker H. Exploiting decellularized cochleae as scaffolds for inner ear tissue engineering. Stem cell research & therapy. 2017;8(1):41.
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Published
2019-12-14
How to Cite
Mehri, A. ., Shojaeian, A. ., & Rezakhani, L. . (2019). A Review on Inner Ear Tissue Engineering. The Journal of Applied Tissue Engineering, 5(3), 1–9. https://doi.org/10.22034/JATE.2018.30
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